High levels of CO 2 increase respiratory rate and tidal volume, and orexin antagonists can blunt this response, especially during wakefulness , Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. The relationship between insomnia and health-related quality of life in patients with chronic illness. Conversely, development of orexin agonists could be immensely helpful for individuals with daytime sleepiness, especially those with narcolepsy. In practice, orexin antagonists will be mainly given at night, and normal orexin signaling during the day should offset any reductions in metabolism or hunger at night. Increased body-mass index in patients with narcolepsy. Antipsychotics such as olanzapine can be very sedating, but they have a relatively high incidence of side effects.
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Orexin Receptors: Pharmacology and Therapeutic Opportunities
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The most reliable studies mapping orexin receptors have examined the distribution of mRNA; studies using immunostaining to detect orexin receptor proteins should be viewed cautiously because many of the current antisera can produce nonspecific staining. Based on the true story of Forrest Tucker and his audacious escape from San Quentin at the age of 70 to an unprecedented string of heists that confounded authorities and enchanted the public. This site is labelled with RTA to prevent entry by minors or other people who might be offended. The orexin-producing neurons also produce glutamate, dynorphin, and probably other neuropeptides derived from prepro-dynorphin 32 , Enjoy it all without limits here! The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin orexin receptor 2 gene.
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